RNA Details
Disease Name
pulmonary hypertension
Tissue
lung
RNA Symbol
Pdcd4
RNA ID
RNA Type
mRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
qRT-PCR; Immunohistochemistry etc.
Target
NA
Pathway
NA
PubMed ID
Title
Endothelial apoptosis in pulmonary hypertension is controlled by a microRNA/programmed cell death 4/caspase-3 axis
Year
2014
Function
A microRNA-21-responsive PDCD4/caspase-3 pathway is existed in the pulmonary tissues that when active serves to promote endothelial apoptosis in vitro and PH in vivo. Direct PDCD4 knockout in mice (PDCD4(-/-) mice) potently blocked pulmonary caspase-3 activation and the development of chronic hypoxia.